deficiencies: other: This is a GLP Guideline study. Reference Endpoint: short-term toxicity to aquatic invertebrates Type of information: experimental study Adequacy of study: key study Study period: 26 to 28 September 2012 Reliability: 1 (reliable without restriction) Rationale for reliability incl. Exposure related observations in humans: other data.Direct observations: clinical cases, poisoning incidents and other.Exposure related observations in humans.Endocrine disrupter mammalian screening – in vivo (level 3).Toxicity to reproduction: other studies.Developmental toxicity / teratogenicity.Toxicokinetics, metabolism and distribution.Nanomaterial radical formation potential. Nanomaterial crystallite and grain size.Nanomaterial agglomeration / aggregation.Additional physico-chemical properties of nanomaterials.Additional physico-chemical information.Storage stability and reactivity towards container material.Stability in organic solvents and identity of relevant degradation products.Solubility in organic solvents / fat solubility.Particle size distribution (Granulometry).
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